PREPARATION AND CHARACTERIZATION OF A CipHCl-PLA/PBC/CS COMPOSITE FIBER MEMBRANE FOR ANTIBACTERIAL WOUND DRESSING

Xiaohua Gu; Dasheng Zhang; Siwen Liu; Yan Liu

doi:10.17222/mit.2022.444

Xiaohua Gu College of Innovative Material and Energy, Qiqihar University, Heilongjiang Qiqihar 161006, China
Dasheng Zhang College of Innovative Material and Energy, Qiqihar University, Heilongjiang Qiqihar 161006, China
Siwen Liu College of Innovative Material and Energy, Hubei University, Hubei 430062, China
Yan Liu School of Energy and Building Environment of Guilin University of Aerospace Technology, Guilin, Guangxi 541004, China

DOI: https://doi.org/10.17222/mit.2022.444

Keywords: polylactic acid, polybutylenes carbonate, chitosan, CipHCl, antibacterial activity

Abstract

In this paper, a polylactic acid (PLA)/polybutylene carbonate (PBC)/chitosan (CS) composite membrane with different mass fractions of ciprofloxacin hydrochloride (CipHCl) drug was prepared through the electrostatic spinning technology. The morphology and chemical structure of the resultant CipHCl-PLA/PBC/CS fiber membranes were characterized with scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). A drug-release test, bacteriostatic test and cytotoxicity test were performed to determine the drug-release properties, bacteriostatic properties and cytotoxicity, respectively. Results show that the CipHCl-PLA/PBC/CS composite fiber membranes have good biocompatibility. When the CipHCl content is 20 w/%, the average fiber diameter is 374 nm. After 192 h, the drug-release rate of the CipHCl-PLA/PBC/CS composite fiber membrane containing 20 w/% of CipHCl reaches 88.2 %. The antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane is much higher than that of the PLA/PBC composite fiber membrane. Besides, the antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane against E. coli is slightly higher than that against S. aureus.

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